pCPA Activity Overview

Status Total Negotiations Summary
Active Negotiations 32 Non-oncology: 20
Oncology: 12
Under Consideration for Negotiation 17 Non-oncology: 6
Oncology: 11
Completed Negotiations 882 With Letter of Intent: 765
Without agreement: 117
Negotiations That Were Not Pursued 114

pCPA activity in the last four weeks

Activity for the last four weeks. Please note that these updates may take one to two weeks to be processed.

Engagement letters issued in the last four weeks

Brand Name Manufacturer Indication Engagement Date
Elahere AbbVie Corporation ​For the treatment of adult patients with folate receptor-alpha (FRα) positive*, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic treatment regimens.
Scemblix Novartis Pharmaceuticals Canada Inc. For the treatment of adult patients with newly diagnosed or previously treated Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP) (first line).
Columvi Hoffmann-La Roche Ltd. In combination with gemcitabine and oxaliplatin for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma not otherwise specified (DLBCL NOS) who are not candidates for autologous stem cell transplant (ASCT).
Voranigo Servier Canada Inc. For the treatment of Grade 2 WHO 2016, 2021 grading system astrocytoma or oligodendroglioma with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation or isocitrate dehydrogenase-2 (IDH2) mutation in adults and pediatric patients aged 12 years and olde
Venclexta AbbVie Corporation In combination with ibrutinib, is indicated for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL).

Negotiations completed in the last four weeks with a letter of intent

Brand Name Manufacturer Indication Engagement Date Close Date
Myfembree Knight Therapeutics Inc. Management of heavy menstrual bleeding associated with uterine fibroids
Omnipod 5 Insulet Canada Corporation Patients with Type 1 Diabetes aged 2 years and old
Opdivo-Yervoy Bristol Myers Squibb Canada Inc. For the first-line treatment of adult patients with unresectable or metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer.
Piasky Hoffmann-La Roche Ltd. Paroxysmal nocturnal hemoglobinuria (PNH)
Jemperli GlaxoSmithKline Inc. ​In combination with carboplatin and paclitaxel for the treatment of adult patients with primary advanced or recurrent endometrial cancer who are candidates for systemic therapy.
Nubeqa Bayer Inc. For the treatment of patients with metastatic castration-sensitive prostate cancer (mCSPC).
Stivarga Bayer Inc. For the treatment of metastatic osteosarcoma in patients who received at least 1 prior line of therapy.
Polivy Hoffmann-La Roche Ltd. In combination with R-CHP for the treatment of adult patients with previously untreated large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), high grade B-cell lymphoma, Epstein-Barr virus-positive (E
Bylvay Medison Pharma Canada Inc. Alagille syndrome
Skyrizi AbbVie Corporation Ulcerative Colitis

Negotiations completed in the last four weeks without agreement

Brand Name Manufacturer Indication Engagement Date Close Date
Wegovy Novo Nordisk Canada Inc. As an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index (BMI) of: 30 kg/m2 or greater (obesity), or 27 kg/m2 or greater (overweight) in the presence of at leas
Pavblu Amgen Canada Inc. Multiple Indications

Negotiations that pCPA decided not to pursue in the last four weeks

Brand Name Manufacturer Indication Close Date
Lumakras Amgen Canada Inc. Advanced non-small cell lung cancer, KRAS G12C-mutated