Brand Name Drug Negotiations Status

The pCPA is a part of the overall Canadian drug approval and reimbursement process. It starts with regulatory approval through Health Canada where drugs are evaluated for efficacy, quality and safety. Following a positive approval from Health Canada, all drugs then go through a health technology assessment for clinical and cost-effectiveness. In Canada there are two review boards, the Canadian Agency for Drugs and Technologies in Health (CADTH) which reviews common drugs through the Common Drug Review (CDR) and oncology drugs through the Pan-Canadian Oncology Drug Review (pCODR). In Quebec, drugs are reviewed through l’Institut national d’excellence en santé et en services sociaux (INESSS). For the majority of new drugs, the pCPA negotiation process begins once a recommendation is published by CADTH and/or INESSS.

Product Manufacturer Status Indication
Cablivi (caplacizumab) SANOFI-AVENTIS Under consideration for negotiation acquired thrombotic thrombocytopenic purpura (aTTP)
Rituxan SC (rituximab) Hoffmann-La Roche Active Negotiation Chronic Lymphocytic Leukemia
Tecentriq & Avastin (Atezolizumab & Bevacizumab) HOFFMANN-LA ROCHE LIMITED Negotiations were not pursued Non-Squamous Non-Small Cell Lung Cancer
Aimovig (erenumab) NOVARTIS PHARMACEUTICALS CANADA INC Under consideration for negotiation migraine, chronic
Vocabria and Cabenuva (cabotegravir and rilpivirine) VIIV HEALTHCARE ULC Under consideration for negotiation HIV Infection
Mayzent (siponimod) NOVARTIS PHARMACEUTICALS CANADA INC Under consideration for negotiation Secondary progressive multiple sclerosis (SPMS)
Vascepa (icosapent ethyl) HLS THERAPEUTICS INC Under consideration for negotiation Ischemic events in statin-treated patients
Stelara (ustekinumab) Janssen Inc. Under consideration for negotiation Ulcerative Colitis
Soliris (eculizumab) Alexion Pharma GMBH Under consideration for negotiation Neuromyelitis optica spectrum disorder (NMOSD)
Darzalex SC (Daratumumab ) Janssen Inc. Active Negotiation Multiple Myeloma
Adcetris (brentuximab vedotin) Seattle Genetics Inc. Active Negotiation Peripheral T-Cell Lymphoma
Cuvposa (Glycopyrrolate) Medexus Inc. Under consideration for negotiation chronic severe drooling, neurologic (pediatric)
Xospata (Gilteritinib) Astellas Pharma Inc. Active Negotiation Acute Myeloid Leukemia
Kisqali (ribociclib) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Advanced or Metastatic Breast Cancer
Kalydeco (ivacaftor) Vertex Pharmaceuticals (Canada) Incorporated Active Negotiation cystic fibrosis in patients with CFTR gating mutations or the R117H gating mutation
Orkambi (lumacaftor/ivacaftor) Vertex Pharmaceuticals (Canada) Incorporated Active Negotiation Cystic Fibrosis, F508del CFTR mutation
Contrave (naltrexone hydrochloride and bupropion hydrochloride) Bausch Health, Canada Inc. Under consideration for negotiation Chronic weight management
Nubeqa (Darolutamide) Bayer Inc. Under consideration for negotiation non-metastatic castrate resistant prostate cancer
Erleada (apalutamide) Janssen Inc. Under consideration for negotiation Metastatic Castration-Sensitive Prostate Cancer
Cabometyx (cabozantinib) Ipsen Biopharmaceuticals Under consideration for negotiation hepatocellular carcinoma
Crysvita (burosumab) Ultragenyx Canada Inc. Under consideration for negotiation X-Linked Hypophosphatemia
Entyvio (SC) (vedolizumab) Takeda Canada Inc. Under consideration for negotiation Ulcerative Colitis
Dupixent (dupilumab) Sanofi Genzyme Active Negotiation Atopic dermatitis
Beovu (brolucizumab) Novartis Pharma Canada Inc. Under consideration for negotiation Age-Related Macular Degeneration
Benlysta (belimumab) GlaxoSmithKline Under consideration for negotiation Systemic lupus erythematosus
Kisqali (with fulvestrant) (ribociclib with fulvestrant) Novartis Pharma Canada Inc. Concluded with an LOI Advanced or Metastatic Breast Cancer
Allerject (epinephrine) Kaleo Inc Concluded with an LOI For the emergency treatment of severe acute allergic reactions (anaphylaxis).
Avsola (infliximab) Amgen Canada Inc. Active Negotiation Ankylosing spondylitis, plaque psoriasis, psoriatic arthritis, rheumatoid arthritis, Crohn’s disease and Ulcerative Colitis
Nivestym (filgrastim) Pfizer Canada ULC Concluded with an LOI Prevention or treatment of neutropenia in various indications
Ziextenzo (pegfilgrastim) Sandoz Canada Concluded with an LOI febrile neutropenia in non-myeloid malignancies
Kanjinti (trastuzumab) Amgen Canada Inc. Concluded with an LOI early breast cancer/metastatic breast cancer/metastatic gastric cancer
Envarsus PA (tacrolimus) Paladin Labs Inc. Concluded with an LOI prophylaxis of organ rejection in allogenic kidney or liver transplant adult patients
Onstryv (safinamide) Valeo Pharma Inc. Under consideration for negotiation Parkinson's Disease
Monoferric (iron (iii) isomaltoside 1000) Pharmacosmos A/S Active Negotiation iron deficiency anemia
Lokelma (sodium zirconium cyclosilicate) AstraZeneca Canada Inc. Negotiations were not pursued hyperkalemia
Taltz (ixekizumab) Eli Lilly Canada Inc. Under consideration for negotiation Ankylosing spondylitis
Vyndaqel (tafamidis) Pfizer Canada ULC Active Negotiation transthyretin-mediated amyloidosis
Rinvoq (upadacitinib) AbbVie Corporation Under consideration for negotiation Subacute and chronic inflammatory joint diseases
Lonsurf (trifluridine/tipiracil) Taiho Pharma Canada Inc. Active Negotiation metastatic Gastric Cancer
Riximyo (rituximab) Sandoz Canada Concluded with an LOI Rheumatoid arthritis, chronic lymphocytic leukemia, and non-Hodgkin’s lymphoma
Ruxience (rituximab) Pfizer Canada ULC Concluded with an LOI Non-Hodgkin's Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL), Rheumatoid Arthritis (RA), Granulomatosis with Polyangitis (GPA), Microscopic Polyangitis (MPA)
Lutathera (lutetium 177 dotatate) Advanced Accelerator Applications Concluded with an LOI Gastroenteropancreatic neuroendocrine tumors (GEP-NETs)
Baqsimi (glucagon) Eli Lilly Canada Inc. Under consideration for negotiation severe hypoglycemia
Admelog (insulin lispro) Sanofi-aventis Canada Inc. Active Negotiation Diabetes Mellitus, Type 1 & 2
Lorbrena (lorlatinib) Pfizer Canada ULC Negotiations were not pursued Non-Small Cell Lung Cancer (ALK+)
Rydapt (midostaurin) Novartis Pharmaceuticals Canada Inc. Negotiations were not pursued Systemic Mastocytosis
Mylotarg (gemtuzumab ozogamicin) Pfizer Canada ULC Concluded with an LOI Acute Myeloid Leukemia
Keytruda (pembrolizumab) Merck Canada Inc. Active Negotiation renal cell carcinoma
Nerlynx (neratinib) Knight Therapeutics Negotiations were not pursued Hormone Receptor-Positive Breast Cancer
Cimzia (certolizumab pegol) UCB Canada Inc. Active Negotiation Psoriasis, moderate to severe plaque
Takhzyro (lanadelumab) Shire Pharma Canada ULC Active Negotiation Hereditary Angioedema
Revestive (teduglutide) Shire Pharma Canada ULC Active Negotiation Short Bowel Syndrome (SBS)
Verkazia (cyclosporine) Santen Incorporated Active Negotiation severe vernal keratoconjunctivitis
Lonsurf (trifluridine/tipiracil) Taiho Pharma Canada Inc. Negotiations were not pursued Metastatic Colorectal Cancer
Mezera (mesalazine) AVIR Pharma Inc. Concluded with an LOI Ulcerative Colitis
Kadcyla (trastuzumab emtansine) Hoffmann-La Roche Active Negotiation early breast cancer
Darzalex (daratumumab) Janssen Inc. Under consideration for negotiation Multiple Myeloma
Keytruda (pembrolizumab) Merck Canada Inc. Concluded with an LOI Squamous Non-Small Cell Lung Cancer
Tecentriq (atezolizumab) Hoffmann-La Roche Under consideration for negotiation Small Cell Lung Cancer
Lynparza (olaparib) AstraZeneca Canada Inc. Active Negotiation Ovarian Cancer
Trintellix (vortioxetine) Lundbeck Canada Inc. Active Negotiation Major Depressive Disorder
Xultophy (insulin degludec/liraglutide) Novo Nordisk Canada Inc. Active Negotiation Diabetes Mellitus, Type 2
Dovato (dolutegravir/lamivudine) ViiV Healthcare Concluded with an LOI HIV Infection
Iluvien (fluocinolone acetonide) Knight Therapeutics Negotiations were not pursued Diabetic Macular Edema
Emerade (epinephrine bitartrate) Bausch Health, Canada Inc. Concluded with an LOI For the emergency treatment of severe acute allergic reactions (anaphylaxis).
Bosulif (bosutinib) Pfizer Canada ULC Concluded with an LOI Chronic Myeloid Leukemia
Olumiant (baricitinib) Eli Lilly Canada Inc. Active Negotiation Subacute and chronic inflammatory joint diseases
Orfadin Oral Suspension (nitisinone) Sobi Canada Inc. Concluded without agreement Hereditary Tyrosinemia Type 1
Onpattro (patisiran) Alnylam Netherlands B.V. Active Negotiation hereditary transthyretin-mediated amyloidosis
Tegsedi (inotersen) Akcea Therapeutics Inc. Concluded with an LOI hereditary transthyretin-mediated amyloidosis
Truxima (rituximab) Teva Canada Limited Concluded with an LOI Rheumatoid arthritis, chronic lymphocytic leukemia, and non-Hodgkin’s lymphoma
Vitrakvi (larotrectinib) Bayer Inc. Negotiations were not pursued Neurotrophic Tyrosine Receptor Kinase (NTRK) Locally Advanced or Metastatic Solid Tumours
Pomalyst (pomalidomide) Celgene Inc. Under consideration for negotiation Multiple Myeloma (Relapsed)
Idhifa (enasidenib) Celgene Inc. Under consideration for negotiation Acute Myeloid Leukemia
Revlimid (lenalidomide) Celgene Inc. Concluded with an LOI Multiple Myeloma
Sublocade (buprenorphine) Indivior UK Limited Concluded with an LOI Opioid Use Disorder
Cystadrops (cysteamine) Recordati Canada Concluded with an LOI corneal cystine crystal deposits
Libtayo (cemiplimab) Sanofi Genzyme Active Negotiation Cutaneous Squamous Cell Carcinoma
Lenvima (lenvatinib) Eisai Limited Concluded with an LOI hepatocellular carcinoma
Darzalex (daratumumab) Janssen Inc. Active Negotiation Multiple Myeloma (newly diagnosed)
Lutathera (lutetium 177 dotatate) Advanced Accelerator Applications Concluded without agreement Gastroenteropancreatic neuroendocrine tumors (GEP-NETs)
Alunbrig (brigatinib) Takeda Canada Inc. Negotiations were not pursued Non-Squamous Non-Small Cell Lung Cancer
Ninlaro (ixazomib) Takeda Canada Inc. Negotiations were not pursued Multiple Myeloma
Verzenio (abemaciclib) Eli Lilly Canada Inc. Concluded without agreement Advanced or Metastatic Breast Cancer
Vizimpro (dacomitinib) Pfizer Canada ULC Concluded without agreement Non-Squamous Non-Small Cell Lung Cancer
Keytruda (pembrolizumab) Merck Canada Inc. Negotiations were not pursued Metastatic Urothelial Carcinoma (first line)
Keytruda (pembrolizumab) Merck Canada Inc. Concluded with an LOI Melanoma adjuvant therapy
Keytruda (pembrolizumab) Merck Canada Inc. Concluded with an LOI Non-Squamous Non-Small Cell Lung Cancer
Venclexta/rituximab (venetoclax/rituximab) AbbVie Corporation Concluded with an LOI Chronic Lymphocytic Leukemia
Xalkori (crizotinib) Pfizer Canada ULC Concluded with an LOI ROS1-positive advanced Non-Small Cell Lung Cancer
Ibrance/fulvestrant (palbociclib/fulvestrant) Pfizer Canada ULC Concluded with an LOI Advanced or Metastatic Breast Cancer
Imfinzi (durvalumab) AstraZeneca Canada Inc. Concluded with an LOI Non-small Cell Lung Cancer
Tafinlar/Mekinist (dabrafenib/trametinib) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Melanoma adjuvant therapy
Trazimera (trastuzumab) Pfizer Canada ULC Concluded with an LOI early breast cancer/metastatic breast cancer/metastatic gastric cancer
Herzuma (trastuzumab) Teva Canada Limited Concluded with an LOI Metastatic Breast Cancer
Ogivri (trastuzumab) BGP Pharma ULC Concluded with an LOI early breast cancer/metastatic breast cancer/metastatic gastric cancer
Opsumit (macitentan) Actelion Pharmaceuticals Ltd. Active Negotiation Pulmonary Arterial Hypertension
Brilinta (ticagrelor) AstraZeneca Canada Inc. Concluded with an LOI secondary prevention of atherothrombotic events
Triamcinolone Hexacetonide (triamcinolone hexacetonide) Medexus Inc. Concluded with an LOI Subacute and chronic inflammatory joint diseases
Skyrizi (risankizumab) AbbVie Corporation Concluded with an LOI Plaque psoriasis
Vyzulta (latanoprostene bunod) Bausch Health, Canada Inc. Concluded with an LOI Open-angle Glaucoma
Blincyto (blinatumomab) Amgen Canada Inc. Concluded with an LOI Philadelphia chromosome positive (Ph+) B-cell precursor (BCP) acute lymphoblastic leukemia (ALL)
Folotyn (pralatrexate) Servier Canada Inc. Concluded with an LOI Peripheral T-Cell Lymphoma
Botox (onabotulinumtoxin a) Allergan Inc. Active Negotiation migraine, chronic
Xermelo (telotristat) Ipsen Biopharmaceuticals Negotiations were not pursued carcinoid syndorme
Jublia (efinaconazole) Bausch Health, Canada Inc. Negotiations were not pursued onychomycosis
Pifletro (doravirine) Merck Canada Inc. Concluded with an LOI HIV Infection
Delstrigo (doravirine/lamuvidine/tenofovir disoproxil fumarate) Merck Canada Inc. Concluded with an LOI HIV Infection
Cresemba (isavuconazole) AVIR Pharma Inc. Concluded with an LOI Treatment of invasive aspergillosis and mucormycosis
Unituxin (dinutuximab) United Therapeutics Concluded with an LOI neuroblastoma
Xtandi (enzalutamide) Astellas Pharma Inc. Concluded with an LOI non-metastatic castrate resistant prostate cancer
Opdivo (nivolumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI Melanoma adjuvant therapy
Adcetris (brentuximab vedotin) Seattle Genetics Inc. Negotiations were not pursued Hodgkin's Lymphoma
Radicava (edaravone) Mitsubishi Tanabe Pharma Corporation Concluded with an LOI amyotrophic lateral sclerosis
Eucrisa (crisaborole) Pfizer Canada ULC Negotiations were not pursued Atopic dermatitis
Brineura (cerliponase alfa) BioMarin Pharmaceutical Inc. Concluded with an LOI neuronal ceroid lipofuscinosis type 2
Kalydeco (ivacaftor) Vertex Pharmaceuticals (Canada) Incorporated Concluded with an LOI cystic fibrosis in patients with CFTR gating mutations or the R117H gating mutation
Zirabev (bevacizumab) Pfizer Canada ULC Concluded with an LOI Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer
Spinraza (nusinersen) Biogen Canada Inc. Concluded with an LOI Spinal Muscular Atrophy
Xeljanz (tofacitinib) Pfizer Canada ULC Concluded with an LOI Ulcerative Colitis
Cabometyx (cabozantinib) Ipsen Biopharmaceuticals Concluded with an LOI renal cell carcinoma
Mvasi (bevacizumab) Amgen Canada Inc. Concluded with an LOI Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer
Ella (ulipristal acetate) Allergan Inc. Concluded with an LOI prevention of pregnancy
Segluromet (ertugliflozin/metformin hydrochloride) Merck Canada Inc. Concluded without agreement Diabetes Mellitus, Type 2
Steglatro (ertugliflozin) Merck Canada Inc. Concluded without agreement Diabetes Mellitus, Type 2
Fulphila (pegfilgastrim) BGP Pharma ULC Concluded with an LOI febrile neutropenia in non-myeloid malignancies
Xeljanz XR (tofacitinib) Pfizer Canada ULC Concluded with an LOI Subacute and chronic inflammatory joint diseases
Humira (citrate-free) (adalimumab citrate-free) AbbVie Corporation Concluded without agreement Multiple Indications
Ozempic (semaglutide) Novo Nordisk Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Herceptin SC (trastuzumab) Hoffmann-La Roche Concluded without agreement breast cancer
Tagrisso (osimertinib) AstraZeneca Canada Inc. Concluded with an LOI first-line treatment of locally advanced or metastatic non-small cell cell lung cancer (NSCLC)
Lenvima (lenvatinib) Eisai Limited Negotiations were not pursued advanced or metastatic, clear-cell renal cell carcinoma
Harvoni (ledipasvir/sofosbuvir) Gilead Sciences Canada Inc. Concluded with an LOI Chronic Hepatitis C
Velphoro (sucroferric oxyhydroxide) Vifor Fresenius Medical Care Renal Pharma Concluded with an LOI Hyperphosphatemia, end-stage renal disease
Soliqua (lixisenatide/insulin glargine) Sanofi-aventis Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Perjeta/Herceptin (pertuzumab/trastuzumab) Hoffmann-La Roche Negotiations were not pursued early breast cancer
Opdivo (nivolumab) Bristol Myers Squibb Canada Inc. Negotiations were not pursued hepatocellular carcinoma
Daklinza (daclatasvir) Bristol Myers Squibb Canada Inc. Concluded with an LOI Chronic Hepatitis C
Januvia (sitagliptin phosphate) Merck Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Yervoy/Opdivo (nivolumab/ipilimumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI renal cell carcinoma
Gazyva (obinutuzumab) Hoffmann-La Roche Negotiations were not pursued Follicular Lymphoma
Erleada (apalutamide) Janssen Inc. Concluded with an LOI non-metastatic castrate resistant prostate cancer
Xarelto (rivaroxaban) Bayer Inc. Concluded with an LOI Prevention of stroke and cardiovascular events in coronary and peripheral artery disease.
Ozurdex (dexamethasone) Allergan Inc. Negotiations were not pursued Diabetic Macular Edema
Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) Gilead Sciences Canada Inc. Concluded with an LOI HIV infection
Fibristal (ulipristal acetate) Allergan Inc. Concluded with an LOI Intermittent treatment of moderate to severe signs and symptoms of uterine fibroids
uterine fibroids
Alecensaro (alectinib) Hoffmann-La Roche Concluded with an LOI Non-Small Cell Lung Cancer (First Line)
Praluent (alirocumab) Sanofi-aventis Canada Inc. Concluded without agreement Atherosclerotic cardiovascular disease
Orkambi (lumacaftor/ivacaftor) Vertex Pharmaceuticals (Canada) Incorporated Negotiations were not pursued Cystic Fibrosis, F508del CFTR mutation
Arbesda RespiClick (fluticasone propionate/salmeterol xinafoate) Teva Canada Limited Concluded without agreement Asthma
Aermony Respiclick (fluticasone propionate) Teva Canada Limited Concluded without agreement Asthma
Viberzi (eluxadoline) Allergan Inc. Negotiations were not pursued Irritable Bowel Syndrome
Kanuma (sebelipase alfa) Alexion Pharma GMBH Active Negotiation Lysosomal acid lipase deficiency
Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) GlaxoSmithKline Concluded with an LOI Chronic Obstructive Pulmonary Disease
Mavenclad (cladribine) EMD Serono a Division of EMD Inc. Canada Concluded with an LOI Relapsing-Remitting Multiple Sclerosis
Nucynta (tapentadol hydrochloride) Paladin Labs Inc. Negotiations were not pursued Pain, severe
Fasenra (benralizumab) AstraZeneca Canada Inc. Concluded with an LOI Eosinophilic Asthma
Dysport Therapeutic (abobotulinumtoxina) Ipsen Biopharmaceuticals Concluded with an LOI Lower Limb Spasticity
Nitisinone (nitisinone) Cycle Pharmaceuticals Ltd. Concluded with an LOI Hereditary Tyrosinemia Type 1
Taltz (ixekizumab) Eli Lilly Canada Inc. Concluded with an LOI Psoriatic Arthritis
Duodopa (levodopa/carbidopa) AbbVie Corporation Concluded with an LOI Parkinson's Disease
Probuphine (buprenorphine) Knight Therapeutics Concluded with an LOI Opioid Use Disorder
Ozanex (ozenoxacin) Ferrer Internacional Negotiations were not pursued Impetigo
Symtuza (darunavir/cobicistat/emtricitabine/tenofovir alafenamide) Janssen Inc. Concluded without agreement HIV infection
Lonsurf (trifluridine/tipiracil) Taiho Pharma Canada Inc. Concluded with an LOI Metastatic Colorectal Cancer
Besponsa (inotuzumab ozogamicin) Pfizer Canada ULC Concluded with an LOI Acute Lymphoblastic Leukemia
Tecentriq (atezolizumab) Hoffmann-La Roche Concluded with an LOI Non-small Cell Lung Cancer
Dupixent (dupilumab) Sanofi Genzyme Concluded with an LOI Atopic dermatitis
Lapelga (pegfilgrastrim) Apobiologix Concluded with an LOI Febrile Neutropenia
Siliq (brodalumab) Valeant Canada Concluded with an LOI Psoriasis, moderate to severe plaque
Prevymis (letermovir) Merck Canada Inc. Concluded with an LOI Cytomegalovirus infection prophylaxis
Juluca (dolutegravir/rilpivirine) ViiV Healthcare Concluded with an LOI HIV infection
Akynzeo (netupitant/palonosetron) Purdue Pharma Concluded with an LOI Nausea and vomiting (chemotherapy induced) prevention
Toujeo (insulin glargine injection) Sanofi-aventis Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 1 & 2
Rituxan SC (rituximab) Hoffmann-La Roche Concluded with an LOI Chronic Lymphocytic Leukemia
Kevzara (sarilumab) Sanofi-aventis Canada Inc. Concluded with an LOI Subacute and chronic inflammatory joint diseases
Dysport Therapeutic (abobotulinumtoxina) Ipsen Biopharmaceuticals Concluded with an LOI Upper Limb Spasticity
Dysport Therapeutic (abobotulinumtoxina) Ipsen Biopharmaceuticals Concluded with an LOI Cervical dystonia
Enstilar (calcipotriol/betamethasone) LEO Pharma Inc. Concluded with an LOI Psoriasis, moderate to severe plaque
Opdivo (nivolumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI Classic Hodgkin's Lymphoma
Kisqali (ribociclib) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Advanced or Metastatic Breast Cancer
Lartruvo (olaratumab) Eli Lilly Canada Inc. Concluded without agreement Advanced Soft Tissue Sarcoma
Stivarga (regorafenib) Bayer Inc. Concluded with an LOI Unresectable Hepatocellular Carcinoma
Alecensaro (alectinib) Hoffmann-La Roche Concluded with an LOI Locally advanced or metastatic non-small cell lung cancer
Vectibix (panitumumab) Amgen Canada Inc. Negotiations were not pursued Left Sided Metastatic Colorectal Cancer
Bavencio (avelumab) EMD Serono a Division of EMD Inc. Canada Concluded with an LOI Metastatic Merkel Cell Carcinoma
Keytruda (pembrolizumab) Merck Canada Inc. Concluded with an LOI Metastatic Urothelial Carcinoma
Venclexta (venetoclax) AbbVie Corporation Concluded with an LOI Chronic Lymphocytic Leukemia
Adcetris (brentuximab vedotin) Seattle Genetics Inc. Concluded with an LOI Hodgkin's Lymphoma
Ocrevus (ocrelizumab) Hoffmann-La Roche Concluded with an LOI Primary Progressive Multiple Sclerosis
MDK-Nitisinone (nitisinone) MendeliKABS Inc Concluded with an LOI Hereditary Tyrosinemia Type 1
Monoprost (latanoprost) Laboratoires Thea Concluded without agreement Glaucoma and Ocular Hypertension
Actemra (tocilizumab) Hoffmann-La Roche Concluded with an LOI Giant Cell Arteritis
Vemlidy (tenofovir alafenamide) Gilead Sciences Canada Inc. Concluded without agreement Hepatitis B
Ilaris (canakinumab) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Systemic juvenile idiopathic arthritis
Renflexis (infliximab) Merck Canada Inc. Concluded with an LOI Rheumatic Conditions
Izba (travoprost) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Open-angle Glaucoma
Rexulti (brexpiprazole) Otsuka Canada Pharmaceuticals Concluded with an LOI Schizophrenia
Galafold (migalastat) Amicus Therapeutics Concluded with an LOI Fabry's Disease
Fiasp (insulin aspart) Novo Nordisk Canada Inc. Concluded without agreement Diabetes Mellitus, Type 1 & 2
Pomalyst (pomalidomide) Celgene Inc. Concluded with an LOI Multiple Myeloma
Mictoryl Pediatric (propiverine hydrochloride) Duchesnay Inc. Concluded with an LOI Overactive bladder
Jevtana (cabazitaxel) Sanofi-aventis Canada Inc. Concluded with an LOI Castrate resistant metastatic prostate cancer
Rosiver (ivermectin) Galderma Canada Inc. Concluded without agreement Rosacea
Rydapt (midostaurin) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Acute Myeloid Leukemia
Lynparza (olaparib) AstraZeneca Canada Inc. Concluded with an LOI Ovarian Cancer
Tagrisso (osimertinib) AstraZeneca Canada Inc. Concluded with an LOI Non-Squamous Non-Small Cell Lung Cancer
Gazyva (obinutuzumab) Hoffmann-La Roche Concluded with an LOI Follicular Lymphoma
Orfadin (nitisinone) Sobi Canada Inc. Concluded with an LOI Hereditary Tyrosinemia Type 1
Tremfya (guselkumab) Janssen Inc. Concluded without agreement Psoriasis, moderate to severe plaque
Procysbi (cysteamine bitartrate) Horizon Therapeutics Ireland DAC Concluded with an LOI Nephropathic cystinosis
Maviret (glecaprevir/pibrentasvir) AbbVie Corporation Concluded with an LOI Chronic Hepatitis C
Movapo (apomorphine hydrochloride) Paladin Labs Inc. Concluded with an LOI Parkinson's Disease
Vosevi (sofosbuvir/velpatasvir/voxilaprevir) Gilead Sciences Canada Inc. Concluded with an LOI Chronic Hepatitis C
Spinraza (nusinersen) Biogen Canada Inc. Concluded with an LOI Spinal Muscular Atrophy
Zykadia (ceritinib) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Non-Squamous Non-Small Cell Lung Cancer
Viacoram (perindopril arginine/amlodipine) Servier Canada Inc. Concluded without agreement Hypertension
Adlyxine (lixisenatide) Sanofi-aventis Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Repatha (evolocumab) Amgen Canada Inc. Concluded without agreement Primary hyperlipidemia and mixed dyslipidemia
Ocrevus (ocrelizumab) Hoffmann-La Roche Concluded with an LOI multiple sclerosis, relapsing
Tresiba (insulin degludec) Novo Nordisk Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 1 & 2
Stivarga (regorafenib) Bayer Inc. Negotiations were not pursued Metastatic Colorectal Cancer
VPRIV (velaglucerase) Shire Pharma Canada ULC Concluded with an LOI Gaucher disease
Elelyso (taliglucerase alfa) Pfizer Canada ULC Concluded with an LOI Gaucher disease
Cerezyme (imiglucerase) Sanofi Genzyme Canada Concluded without agreement Gaucher disease
Kyleena (levonorgestrel) Bayer Inc. Concluded with an LOI Conception Control
Invega Trinza (paliperidone palmitate) Janssen Inc. Concluded with an LOI Schizophrenia
Strensiq (asfotase alfa) Alexion Pharma GMBH Concluded with an LOI pediatric-onset hypophosphatasia
Narcan (naloxone hydrochloride) Adapt Pharma Operations Limited Concluded with an LOI Opioid Overdose
Methadose (methadone hydrochloride) Mallinckrodt Canada ULC Concluded without agreement Opioid Dependence
Metoject (methotrexate) Medexus Inc. Concluded with an LOI Rheumatic Conditions
Copaxone (glatiramer acetate) Teva Canada Limited Concluded without agreement Clinically Isolated Syndrome
Botox (onabotulinumtoxin a) Allergan Inc. Concluded with an LOI Multiple Indications
Faslodex (fulvestrant) AstraZeneca Canada Inc. Concluded without agreement Locally Advanced or Metastatic Breast Cancer
Keytruda (pembrolizumab) Merck Canada Inc. Concluded with an LOI Classic Hodgkin's Lymphoma
Onivyde (irinotecan liposome) Shire Pharma Canada ULC Concluded without agreement Metastatic Pancreatic Cancer
Yervoy/Opdivo (nivolumab/ipilimumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI Metastatic Melanoma
Glatect (glatiramer acetate) Pendopharm Concluded with an LOI Multiple Sclerosis, relapsing - remitting
Cerdelga (eliglustat) Sanofi Genzyme Canada Concluded without agreement Gaucher disease
Ocaliva (obeticholic acid) Intercept Pharma Canada Concluded with an LOI Primary biliary cholangitis
Caprelsa (vandetanib) Sanofi Genzyme Canada Concluded with an LOI Medullary Thyroid Cancer
Erelzi (etanercept) Sandoz Canada Inc. Concluded with an LOI Ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, rheumatoid arthritis
Zinbryta (daclizumab beta) Biogen Canada Inc. Negotiations were not pursued Multiple Sclerosis, relapsing
Darzalex (daratumumab) Janssen Inc. Concluded with an LOI Multiple Myeloma
Lixiana (edoxaban) Servier Canada Inc. Concluded with an LOI Venous thromboembolism, treatment and recurrence prevention
Odefsey (emtricitabine/rilpivirine/tenofovir alafenamide) Gilead Sciences Canada Inc. Concluded with an LOI HIV infection
Lancora (ivabradine) Servier Canada Inc. Concluded with an LOI Heart failure, NYHA class II or III
Fibristal (ulipristal acetate) Allergan Inc. Concluded without agreement Uterine fibroids (signs and symptoms) - 2nd cycle pre-surgery
Mictoryl (propiverine hydrochloride) Duchesnay Inc. Concluded without agreement Overactive bladder
Kevzara (sarilumab) Sanofi-aventis Canada Inc. Concluded without agreement Subacute and chronic inflammatory joint diseases
Blincyto (blinatumomab) Amgen Canada Inc. Concluded with an LOI Acute Lymphoblastic Leukemia
Actikerall (fluorouracil/salicylic acid) Cipher Concluded with an LOI Hyperkeratotic actinic keratosis
Stelara (ustekinumab) Janssen Inc. Concluded without agreement Crohn's disease
Lixiana (edoxaban) Servier Canada Inc. Concluded with an LOI Non-valvular atrial fibrillation, prevention of stroke and systemic embolism
Blincyto (blinatumomab) Amgen Canada Inc. Concluded with an LOI Pediatric Acute Lymphoblastic Leukemia (ALL)
Ravicti (glycerol phenylbutyrate) Horizon Therapeutics Ireland DAC Concluded with an LOI Urea cycle disorders
Hemangiol (propranolol oral solution) Pierre Fabre Concluded with an LOI Infantile hemangioma
Brivlera (brivaracetam) UCB Canada Inc. Concluded with an LOI Epilepsy, partial-onset seizures
Ibrance (palbociclib) Pfizer Canada ULC Concluded with an LOI Advanced Breast Cancer
Quinsair (levofloxacin) Raptor Pharmaceuticals Inc. Concluded with an LOI Cystic fibrosis with chronic pulmonary Pseudomonas aeruginosa infections
Rituxan (rituximab) Hoffmann-La Roche Negotiations were not pursued Acute Lymphoblastic Leukemia
Kyprolis (carfilzomib) Amgen Canada Inc. Concluded with an LOI Multiple Myeloma
Uptravi (selexipag) Actelion Pharmaceuticals Ltd. Concluded with an LOI Pulmonary Arterial Hypertension
Synjardy (empagliflozin/metformin) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Diabetes Mellitus, Type 2
Taltz (ixekizumab) Eli Lilly Canada Inc. Concluded with an LOI Psoriasis, moderate to severe plaque
Kuvan (sapropterin dihydrochloride) BioMarin Pharmaceutical Inc. Concluded with an LOI Phenylketonuria
Jardiance (empagliflozin) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Diabetes Mellitus, Type 2 with high cardiovascular risk
Invokamet (canagliflozin/metformin hydrochloride) Janssen Inc. Concluded without agreement Diabetes Mellitus, Type 2
Brilinta (ticagrelor) AstraZeneca Canada Inc. Concluded without agreement Prevention of atherothrombotic events with history of myocardial infarction
Descovy (emtricitabine/tenofovir alafenamide) Gilead Sciences Canada Inc. Concluded without agreement HIV infection
Cosentyx (secukinumab) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Ankylosing spondylitis
Cosentyx (secukinumab) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Psoriatic Arthritis
Revestive (teduglutide) Shire Pharma Canada ULC Concluded with an LOI Short Bowel Syndrome (SBS)
Praluent (alirocumab) Sanofi-aventis Canada Inc. Concluded with an LOI Primary hypercholesterolemia (non-familial and heterozygous familial)
Kyprolis (carfilzomib) Amgen Canada Inc. Concluded with an LOI Multiple Myeloma
Trulicity (dulaglutide) Eli Lilly Canada Inc. Concluded without agreement Diabetes Mellitus, Type 2
Nucala (mepolizumab) GlaxoSmithKline Concluded with an LOI Severe Eosinophilic Asthma
Vimizim (elosulfase alfa) BioMarin Pharmaceutical Inc. Concluded with an LOI Mucopolysaccharidosis IVA (Morquio A syndrome)
Xolair (omalizumab) Novartis Pharmaceuticals Canada Inc. Concluded without agreement Severe Persistent Asthma
Fycompa (perampanel) Eisai Limited Concluded with an LOI Epilepsy, primary generalized tonic-clonic seizures
Pheburane (sodium phenylbutyrate) Médunik Concluded with an LOI Urea cycle disorders
Naglazyme (galsulfase) BioMarin Pharmaceutical Inc. Negotiations were not pursued Mucopolysaccharidosis VI
Repatha (evolocumab) Amgen Canada Inc. Concluded with an LOI Primary hyperlipidemia and mixed dyslipidemia
Prolia (denosumab) Amgen Canada Inc. Concluded with an LOI Osteoporosis in Men
Kalydeco (ivacaftor) Vertex Pharmaceuticals (Canada) Incorporated Concluded without agreement Cystic Fibrosis (CFTR gating mutations)
Truvada (emtricitabine/tenofovir disoproxil fumarate) Gilead Sciences Canada Inc. Negotiations were not pursued HIV infection, pre-exposure prophylaxis
Strensiq (asfotase alfa) Alexion Pharma GMBH Concluded without agreement pediatric-onset hypophosphatasia
Tafinlar/Mekinist (dabrafenib/trametinib) Novartis Pharmaceuticals Canada Inc. Negotiations were not pursued Non-Small Cell Lung Cancer (with CNS metastases)
Giotrif (afatinib) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Advanced Non Small Cell Lung Cancer
Opdivo (nivolumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI Squamos Cell Carcinoma of the Head and Neck
Simponi IV (golimumab) Janssen Inc. Concluded without agreement Subacute and chronic inflammatory joint diseases
Stivarga (regorafenib) Bayer Inc. Concluded with an LOI Gastrointestinal Stromal Tumours
Basaglar (insulin glargine) Eli Lilly Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 1 & 2
Mifegymiso (mifepristone and misoprostol) Celopharma Concluded with an LOI Medical termination of pregnancy
Keytruda (pembrolizumab) Merck Canada Inc. Concluded with an LOI Non-small Cell Lung Cancer
Keytruda (pembrolizumab) Merck Canada Inc. Concluded with an LOI Non-small Cell Lung Cancer
Neupro (rotigotine) UCB Canada Inc. Concluded with an LOI Parkinson's Disease
Brenzys (etanercept) Merck Canada Inc. Concluded with an LOI Rheumatoid Arthritis and Ankylosing Spondylitis
Afinitor (everolimus) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Neuroendocrine tumours of Gastrointestinal or Lung origin
XigDuo (dapagliflozin/metformin hydrochloride) AstraZeneca Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Humira (adalimumab) AbbVie Corporation Concluded with an LOI Ulcerative Colitis
Avastin (bevacizumab) Hoffmann-La Roche Concluded with an LOI Platinum-Resistant Ovarian Cancer
Avastin (bevacizumab) Hoffmann-La Roche Concluded with an LOI Metastatic Colorectal Cancer
Sublinox (zolpidem tartrate) Valeant Canada Negotiations were not pursued Insomnia, short-term treatment
Ninlaro (ixazomib) Takeda Canada Inc. Negotiations were not pursued Multiple Myeloma
Eylea (aflibercept) Bayer Inc. Concluded with an LOI Macular edema secondary to branch retinal vein occlusion
Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) Gilead Sciences Canada Inc. Concluded with an LOI HIV infection
Entresto (sacubitril/valsartan) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Heart failure, NYHA class II or III
Entyvio (vedolizumab) Takeda Canada Inc. Concluded with an LOI Crohn's disease
Entyvio (vedolizumab) Takeda Canada Inc. Concluded with an LOI Ulcerative Colitis
Epclusa (sofosbuvir/velpatasvir) Gilead Sciences Canada Inc. Concluded with an LOI Chronic Hepatitis C
Sunvepra (asunaprevir) Bristol Myers Squibb Canada Inc. Concluded with an LOI Chronic Hepatitis C
Zepatier (elbasvir/grazoprevir) Merck Canada Inc. Concluded with an LOI Chronic Hepatitis C
Otezla (apremilast) Celgene Inc. Concluded without agreement Psoriatic Arthritis
Plegridy (peginterferon beta-1a) Biogen Canada Inc. Concluded with an LOI Multiple Sclerosis, relapsing
Opsumit (macitentan) Actelion Pharmaceuticals Ltd. Concluded without agreement Pulmonary Arterial Hypertension
Caprelsa (vandetanib) Sanofi Genzyme Canada Concluded without agreement Medullary Thyroid Cancer
Jakavi (ruxolintib) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Polycythemia vera
Alecensaro (alectinib) Hoffmann-La Roche Negotiations were not pursued Non-Small Cell Lung Cancer (with CNS metastases)
Stelara (ustekinumab) Janssen Inc. Negotiations were not pursued Psoriatic Arthritis
Votrient (pazopanib hydrochloride) GlaxoSmithKline Concluded with an LOI Metastatic Renal Cell Carcinoma
Signifor (pasireotide diaspartate) Novartis Pharmaceuticals Canada Inc. Negotiations were not pursued Cushing's disease
Samsca (tolvaptan) Otsuka Canada Pharmaceuticals Negotiations were not pursued Hyponatremia, non-hypovolemic
Imbruvica (ibrutinib) Janssen Inc. Concluded with an LOI Chronic Lymphocytic Leukemia
Grastofil (filgrastim) ApoPharm Inc. Concluded with an LOI Prevention or treatment of neutropenia in various indications
Xolair (omalizumab) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Chronic Idiopathic Urticaria
Imbruvica (ibrutinib) Janssen Inc. Concluded with an LOI Mantle Cell Lymphoma
Lenvima (lenvatinib) Eisai Limited Concluded with an LOI Differentiated Thyroid Cancer
Mozobil (plerixafor) Sanofi-aventis Canada Inc. Concluded with an LOI Non-Hodgkin's Lymphoma and Multiple Myeloma
Rituxan SC (rituximab) Hoffmann-La Roche Concluded with an LOI ALL for ritux sub-cu
Otezla (apremilast) Celgene Inc. Concluded without agreement Psoriasis, moderate to severe plaque
Forxiga (dapagliflozin) AstraZeneca Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Vectibix (panitumumab) Amgen Canada Inc. Concluded with an LOI Metastatic Colorectal Cancer
Cotellic (cobimetinib) Hoffmann-La Roche Concluded with an LOI Metastatic Melanoma
Esbriet (pirfenidone) Hoffmann-La Roche Concluded with an LOI Pulmonary fibrosis (idiopathic, mild to moderate)
Ferriprox (deferiprone) ApoPharm Inc. Concluded with an LOI Transfusional iron overload
Ofev (nintedanib) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Idiopathic pulmonary fibrosis (IPF)
Simponi SC (golimumab) Janssen Inc. Concluded with an LOI Ulcerative Colitis
Arnuity Ellipta (fluticasone furoate) GlaxoSmithKline Concluded with an LOI Asthma
Breo Ellipta (fluticasone furoate/vilanterol) GlaxoSmithKline Concluded with an LOI Asthma
Opdivo (nivolumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI Metastatic Renal Cell Carcinoma
Cosentyx (secukinumab) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Psoriasis, moderate to severe plaque
Opdivo (nivolumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI Non-small Cell Lung Cancer
Opdivo (nivolumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI Metastatic Melanoma
Lemtrada (alemtuzumab) Sanofi Genzyme Canada Concluded with an LOI Relapsing-Remitting Multiple Sclerosis
Xeljanz (tofacitinib) Pfizer Canada ULC Concluded with an LOI Subacute and chronic inflammatory joint diseases
Daklinza (daclatasvir) Bristol Myers Squibb Canada Inc. Concluded without agreement Chronic Hepatitis C
Zydelig (idelalisib) Gilead Sciences Canada Inc. Negotiations were not pursued Follicular Lymphoma
Jardiance (empagliflozin) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Diabetes Mellitus, Type 2 with high cardiovascular risk
Trajenta/Jentaduo (linagliptin (linagliptin/metformin)) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Diabetes Mellitus, Type 2
Nesina (alogliptin) Takeda Canada Inc. Negotiations were not pursued Diabetes Mellitus, Type 2
Prezcobix (darunavir/cobicistat) Janssen Inc. Concluded with an LOI HIV Infection
Inspiolto Respimat (tiotropium/olodaterol) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Heart failure, NYHA class II
Spiriva Respimat (tiotropium bromide) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Chronic Obstructive Pulmonary Disease
Byetta (exenatide) AstraZeneca Canada Inc. Concluded without agreement Diabetes Mellitus, Type 2
Blincyto (blinatumomab) Amgen Canada Inc. Concluded with an LOI Acute Lymphoblastic Leukemia
Januvia (sitagliptin phosphate) Merck Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Janumet (sitagliptin phosphate) Merck Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Kazano (alogliptin/metformin) Takeda Canada Inc. Negotiations were not pursued Diabetes Mellitus, Type 2
Cimzia (certolizumab pegol) UCB Canada Inc. Concluded with an LOI Ankylosing spondylitis
Butrans (buprenorphine) Purdue Pharma Concluded without agreement Pain, persistent (moderate intensity)
Actemra SC (tocilizumab) Hoffmann-La Roche Concluded with an LOI Subacute and chronic inflammatory joint diseases
Incruse Ellipta (umeclidinium) GlaxoSmithKline Concluded with an LOI Chronic Obstructive Pulmonary Disease
Duaklir Genuair (aclidinium bromide/formoterol fumarate dihydrate) AstraZeneca Canada Inc. Concluded with an LOI Chronic Obstructive Pulmonary Disease
Inflectra (infliximab) Hospira Healthcare Corporation Concluded with an LOI Ankylosing spondylitis, plaque psoriasis, psoriatic arthritis, rheumatoid arthritis
Jinarc (tolvaptan) Otsuka Canada Pharmaceuticals Negotiations were not pursued Autosomal dominant polycystic kidney disease (ADPKD)
Imbruvica (ibrutinib) Janssen Inc. Negotiations were not pursued Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Darzalex (daratumumab) Janssen Inc. Negotiations were not pursued Multiple Myeloma
Intuniv XR (guanfacine hydrochloride) Shire Pharma Canada ULC Negotiations were not pursued Attention-deficit/hyperactivity disorder (ADHD)
Aptiom (eslicarbazepine acetate) Sunovion Pharmaceuticals Canada Inc. Concluded with an LOI Epilepsy, partial-onset seizures
Simbrinza (brinzolamide/brimonidine) Alcon Concluded with an LOI Glaucoma and Ocular Hypertension
Humira (adalimumab) AbbVie Corporation Negotiations were not pursued Hidradenitis Suppurativa
Cyramza (ramucirumab) Eli Lilly Canada Inc. Concluded with an LOI Advanced or Metastatic Gastric Cancer or Gastro-esophageal Junction (GEJ) Adenocarcinoma
Eliquis (apixaban) Bristol Myers Squibb Canada Inc. Concluded with an LOI Thromboembolic events (venous), treatment and prevention of recurrence
Holkira Pak (ombitasvir/paritaprevir/ritonavir/dasabuvir) AbbVie Corporation Concluded with an LOI Chronic Hepatitis C
Abilify Maintena (aripiprazole) Otsuka Canada Pharmaceuticals Concluded with an LOI Schizophrenia
Grastek (phleum pratense) Merck Canada Inc. Negotiations were not pursued Allergy
Yondelis (trabectedin) Janssen Inc. Negotiations were not pursued Metastatic Liposarcoma or Leiomyosarcoma
Fentora (fentanyl buccal) Teva Canada Limited Negotiations were not pursued Pain (breakthrough), cancer (adults)
Fampyra (fampridine) Biogen Canada Inc. Negotiations were not pursued Multiple Sclerosis, improve walking disability
Sylvant (siltuximab) Janssen Inc. Concluded with an LOI Multicentric Castleman's Disease (MCD)
Anoro Ellipta (umeclidinium/vilanterol) GlaxoSmithKline Concluded with an LOI Chronic Obstructive Pulmonary Disease
Revlimid (lenalidomide) Celgene Inc. Concluded with an LOI Multiple Myeloma (newly diagnosed)
Rebif (interferon beta-1a) EMD Serono a Division of EMD Inc. Canada Concluded with an LOI Clinically Isolated Syndrome
Ultibro Breezhaler (indacaterol/glycopyrronium) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Chronic Obstructive Pulmonary Disease
Myrbetriq (mirabegron) Astellas Pharma Inc. Concluded with an LOI Overactive Bladder
Tivicay (dolutegravir) ViiV Healthcare Concluded with an LOI HIV Infection
Inspra (eplerenone) Pfizer Canada ULC Concluded with an LOI Post myocardial infarction
Iclusig (ponatinib) Paladin Labs Inc. Concluded with an LOI Chronic Myeloid Leukemia/Acute Lymphoblastic Leukemia
Sovaldi (sofosbuvir) Gilead Sciences Canada Inc. Concluded with an LOI Chronic Hepatitis C
Breo Ellipta (fluticasone furoate/vilanterol) GlaxoSmithKline Concluded with an LOI Chronic Obstructive Pulmonary Disease
Egrifta (tesamorelin) Theratechnologies Inc. Negotiations were not pursued Lipodystrophy, HIV-infected patients
Edarbyclor (azilsartan medoxomil/chlorthalidone) Takeda Canada Inc. Negotiations were not pursued Hypertension
Zydelig (idelalisib) Gilead Sciences Canada Inc. Concluded with an LOI Chronic Lymphocytic Leukemia
Edarbi (azilsartan medoxomil) Takeda Canada Inc. Negotiations were not pursued Hypertension
Dymista (azelastine/fluticasone propionate) Meda Pharmaceuticals Negotiations were not pursued Seasonal allergic rhinitis
Tafinlar/Mekinist (dabrafenib/trametinib) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Metastatic Melanoma
Cortiment (budesonide) Ferring Negotiations were not pursued Ulcerative Colitis
Jetrea (ocriplasmin) Alcon Concluded with an LOI Vitreomacular Adhesion
Constella (linaclotide) Forest Laboratories Canada Negotiations were not pursued Irritable bowel syndrome with constipation
Xarelto (rivaroxaban) Bayer Inc. Concluded with an LOI Thromboembolic events (venous), pulmonary embolism
Keytruda (pembrolizumab) Merck Canada Inc. Concluded with an LOI Metastatic Melanoma
Zykadia (ceritinib) Novartis Pharmaceuticals Canada Inc. Negotiations were not pursued Non-Small Cell Lung Cancer (metastatic)
Bosulif (bosutinib) Pfizer Canada ULC Concluded with an LOI Chronic Myeloid Leukemia
Bystolic (nebivolol) Allergan Inc. Negotiations were not pursued Hypertension
Avastin (bevacizumab) Hoffmann-La Roche Concluded with an LOI Cervical Cancer
Xalkori (crizotinib) Pfizer Canada ULC Concluded with an LOI Non-Small Cell Lung Cancer (First Line)
Istodax (romidepsin) Celgene Inc. Concluded with an LOI Peripheral T-Cell Lymphoma
Perjeta (Perjeta/Herceptin) (pertuzumab) Hoffmann-La Roche Negotiations were not pursued Neoadjuvant Breast Cancer
Apprilon (doxycycline monohydrate) Galderma Canada Inc. Negotiations were not pursued Rosacea
Nexavar (sorafenib) Bayer Inc. Negotiations were not pursued Metastatic Progressive Differentiated Thyroid Carcinoma
Aloxi IV (palonosetron hydrochloride) Eisai Limited Negotiations were not pursued Nausea and vomiting (chemotherapy induced) prevention
Aloxi (palonosetron hydrochloride) Eisai Limited Negotiations were not pursued Nausea and vomiting (chemotherapy induced) prevention
Xtandi (enzalutamide) Astellas Pharma Inc. Concluded with an LOI Metastatic Castration Resistant Prostate Cancer
Afinitor (everolimus) Novartis Pharmaceuticals Canada Inc. Negotiations were not pursued Subependymal giant cell astrocytoma associated with tuberous sclerosis complex
Imbruvica (ibrutinib) Janssen Inc. Concluded with an LOI Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Gazyva (obinutuzumab) Hoffmann-La Roche Concluded with an LOI Chronic Lymphocytic Leukemia
Abraxane (nab-paclitaxel) Celgene Inc. Concluded with an LOI Metastatic Pancreatic Cancer
Yervoy (ipilimumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI First Line Advanced Melanoma
Arzerra (ofatumumab) GlaxoSmithKline Negotiations were not pursued Chronic Lymphocytic Leukemia
Afinitor (everolimus) Novartis Pharmaceuticals Canada Inc. Negotiations were not pursued renal angiomyolipoma associated with tuberous sclerosis complex (TSC)
Adempas (riociguat) Bayer Inc. Negotiations were not pursued Pulmonary Arterial Hypertension (WHO group 1)
Abilify (aripiprazole) Bristol Myers Squibb Canada Inc. Negotiations were not pursued Major Depressive Disorder
Pomalyst (pomalidomide) Celgene Inc. Concluded with an LOI Multiple Myeloma
Zaltrap (aflibercept) Regeneron Negotiations were not pursued Metastatic Colorectal Cancer
Effient (prasugrel) Eli Lilly Canada Inc. Concluded with an LOI Acute Coronary Syndrome
Seebri (glycopyrronium bromide) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Chronic Obstructive Pulmonary Disease
Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate) Gilead Sciences Canada Inc. Concluded with an LOI HIV infection
Stivarga (regorafenib) Bayer Inc. Concluded with an LOI Gastrointestinal Stromal Tumours
Abilify (aripiprazole) Bristol Myers Squibb Canada Inc. Concluded without agreement Schizophrenia and Related Psychotic Disorders
Tysabri (natalizumab) Biogen Canada Inc. Concluded with an LOI Relapsing-Remitting Multiple Sclerosis
Revlimid (lenalidomide) Celgene Inc. Concluded with an LOI Multiple Myeloma
Giotrif (afatinib) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Advanced Non Small Cell Lung Cancer
Mekinist (trametinib) GlaxoSmithKline Concluded with an LOI Metastatic Melanoma
Onbrez (indacaterol) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Chronic Obstructive Pulmonary Disease
Gilenya (fingolimod) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Multiple Sclerosis
Tafinlar (dabrafenib) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Metastatic Melanoma
Xarelto (rivaroxaban) Bayer Inc. Concluded with an LOI Atrial fibrillation, stroke prevention
Pradaxa (dabigatran etexilate) Boehringer Ingelheim (Canada) Ltd. Ltee. Concluded with an LOI Atrial fibrillation prevention of stroke and systemic embolism
Victoza (liraglutide) Novo Nordisk Canada Inc. Concluded without agreement Diabetes Mellitus, Type 2
Humira (adalimumab) AbbVie Corporation Concluded with an LOI Hidradenitis Suppurativa
Cinqair (reslizumab) Teva Canada Limited Concluded without agreement Eosinophilic Asthma
Erivedge (vismodegib) Hoffmann-La Roche Concluded with an LOI Advanced Basal Cell Carcinoma
Kadcyla (trastuzumab emtansine) Hoffmann-La Roche Concluded with an LOI Metastatic Breast Cancer
Alimta (pemetrexed) Eli Lilly Canada Inc. Concluded with an LOI Advanced Non-Squamous Non Small Cell Lung Cancer
Adcetris (brentuximab vedotin) Seattle Genetics Inc. Concluded with an LOI Systemic Anaplastic Large Cell Lymphoma
Xiaflex (collagenase clostridium histolyticum) Auxillium Pharmaceuticals Inc. Negotiations were not pursued Dupuytren’s contracture with a palpable cord
Xgeva (denosumab) Amgen Canada Inc. Negotiations were not pursued Prevention of skeletal-related events due to bone metastases from breast cancer
Zytiga (abiraterone) Janssen Inc. Concluded with an LOI Metastatic Castration Resistant Prostate Cancer
Victoza (liraglutide) Novo Nordisk Canada Inc. Concluded without agreement Diabetes Mellitus, Type 2
Erbitux (cetuximab) Eli Lilly Canada Inc. Negotiations were not pursued Metastatic Colorectal Cancer
Votrient (pazopanib hydrochloride) GlaxoSmithKline Concluded with an LOI Metastatic Renal Cell Carcinoma
Technivie (ombitasvir/paritaprevir/ritonavir) AbbVie Corporation Concluded without agreement Chronic Hepatitis C (genotype 4)
Soliris (eculizumab) Alexion Pharma GMBH Concluded without agreement Atypical Hemolytic Uremic Syndrome
Inlyta (axitinib) Pfizer Canada ULC Concluded with an LOI Metastatic Renal Cell Carcinoma
Perjeta/Herceptin (pertuzumab/trastuzumab) Hoffmann-La Roche Concluded with an LOI Metastatic Breast Cancer
Afinitor (everolimus) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Pancreatic Neuroendocrine Tumors
Jadenu (deferasirox) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Chronic Iron Overload
Rosiver (ivermectin) Galderma Canada Inc. Concluded without agreement Rosacea
Sovaldi (sofosbuvir) Gilead Sciences Canada Inc. Concluded with an LOI Chronic Hepatitis C
Xtandi (enzalutamide) Astellas Pharma Inc. Concluded with an LOI Metastatic Castration Resistant Prostate Cancer
Metadol-D (methadone hydrochloride) Paladin Labs Inc. Concluded with an LOI Opioid Dependence
Revolade (eltrombopag) GlaxoSmithKline Negotiations were not pursued Thrombocytopenia associated with chronic hepatitis c infection
Picato (ingenol mebutate) LEO Pharma Inc. Negotiations were not pursued Actinic keratosis
Inflectra (infliximab) Hospira Healthcare Corporation Concluded with an LOI Ankylosing spondylitis, plaque psoriasis, psoriatic arthritis, rheumatoid arthritis, Crohn’s disease and Ulcerative Colitis
Replagal (agalsidase alfa) Shire Pharma Canada ULC Concluded with an LOI Fabry's Disease
Fabrazyme (agalsidase beta) Sanofi Genzyme Canada Concluded with an LOI Fabry's Disease
Orkambi (lumacaftor/ivacaftor) Vertex Pharmaceuticals (Canada) Incorporated Negotiations were not pursued Cystic Fibrosis, F508del CFTR mutation
Jakavi (ruxolintib) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Myelofibrosis
Tobi Podhaler (tobramycin) Novartis Pharmaceuticals Canada Inc. Concluded with an LOI Pseuodomonas aeruginosa infections in cystic fibrosis
Campral (acamprosate calcium) Mylan Pharmaceuticals LLC Concluded without agreement Alcohol Abstinence
Sutent (sunitinib malate) Pfizer Canada ULC Concluded with an LOI Pancreatic Neuroendocrine Tumors
Zaxine (rifaximin) Lupin Pharma Canada Limited Concluded with an LOI Hepatic Encephalopathy
Juxtapid (lomitapide) Aegerion Pharmaceuticals Canada Ltd. Negotiations were not pursued Homozygous Familial Hypercholesterolemia
Tykerb & Letrozole (lapatinib) GlaxoSmithKline Negotiations were not pursued Metastatic Breast Cancer
Xalkori (crizotinib) Pfizer Canada ULC Concluded with an LOI Non-Squamous Non-Small Cell Lung Cancer
Fibristal (ulipristal acetate) Allergan Inc. Concluded with an LOI Uterine fibroids (signs and symptoms)
Firazyr (icatibant) Shire Pharma Canada ULC Concluded with an LOI Hereditary Angioedema
Invokana (canagliflozin) Janssen Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Diacomit (stiripentol) Biocodex SA Concluded with an LOI Dravet Syndrome
Triumeq (dolutegravir/abacavir/lamivudine) ViiV Healthcare Concluded with an LOI HIV Infection
Eylea (aflibercept) Bayer Inc. Concluded with an LOI Age-Related Macular Degeneration
Ibavyr (ribavirin) Pendopharm Concluded with an LOI Chronic Hepatitis C
Halaven (eribulin) Eisai Limited Concluded with an LOI Metastatic Breast Cancer
Remicade (infliximab) Janssen Inc. Concluded with an LOI rheumatoid arthritis, ulcerative colitis and Crohn’s disease
Harvoni (ledipasvir/sofosbuvir) Gilead Sciences Canada Inc. Concluded with an LOI Chronic Hepatitis C
Advair (salmeterol xinafoate/fluticasone propionate) GlaxoSmithKline Concluded with an LOI Chronic Obstructive Pulmonary Disease and asthma
Valtrex (valacyclovir) GlaxoSmithKline Concluded with an LOI Specific Viral Infections
Adempas (riociguat) Bayer Inc. Concluded with an LOI Pulmonary hypertension, chronic thromboembolic
Onglyza (saxagliptin) AstraZeneca Canada Inc. Concluded with an LOI Diabetes Mellitus, Type 2
Soliris (eculizumab) Alexion Pharma GMBH Concluded with an LOI Paroxysmal nocturnal hemoglobinuria (PNH)
Aubagio (teriflunomide) Sanofi Genzyme Canada Concluded with an LOI Multiple Sclerosis, relapsing
Orencia (abatacept) Bristol Myers Squibb Canada Inc. Concluded with an LOI Subacute and chronic inflammatory joint diseases
Galexos (simeprevir) Janssen Inc. Concluded with an LOI Chronic Hepatitis C
Esbriet (pirfenidone) Hoffmann-La Roche Concluded with an LOI Pulmonary fibrosis (idiopathic, mild to moderate)
Tudorza Genuair (aclidinium bromide) AstraZeneca Canada Inc. Concluded with an LOI Chronic Obstructive Pulmonary Disease
Kalydeco (ivacaftor) Vertex Pharmaceuticals (Canada) Incorporated Concluded with an LOI Cystic Fibrosis patients (G551D mutation)
Lodalis (colesevelam hydrochloride) Valeant Canada Concluded with an LOI Hypercholesterolemia
Tecfidera (dimethyl fumarate) Biogen Canada Inc. Concluded with an LOI Multiple Sclerosis, relapsing
Treanda (bendamustine hydrochloride) Lundbeck Canada Inc. Concluded with an LOI Non-Hodgkin's Lymphoma
Oralair (grass pollen allergen extract) Paladin Labs Inc. Concluded with an LOI Allergic Rhinitis
Benlysta (belimumab) GlaxoSmithKline Negotiations were not pursued Systemic lupus erythematosus
Mozobil (plerixafor) Sanofi-aventis Canada Inc. Concluded with an LOI Non-Hodgkin's Lymphoma and Multiple Myeloma
Yervoy (ipilimumab) Bristol Myers Squibb Canada Inc. Concluded with an LOI Advanced Melanoma
Dificid (fidaxomicin) Optimer Pharmaceuticals Concluded with an LOI Clostridium difficile infection
Eliquis (apixaban) Bristol Myers Squibb Canada Inc. Concluded with an LOI Thromboembolic events prevention, (atrial fibrillation)
Replagal (agalsidase alfa) Shire Pharma Canada ULC Concluded with an LOI Fabry's Disease
Fabrazyme (agalsidase beta) Sanofi Genzyme Canada Concluded with an LOI Fabry's Disease
Brilinta (ticagrelor) AstraZeneca Canada Inc. Concluded with an LOI Thrombotic events in Acute Coronary Syndromes, Prevention